Tetrahydrofuran → 2-{2-[5-(4-Fluoro-phenyl)-3-(2,4,6-trifluoro-benzoyl)-2,3-dihydro-[1,3,4]thiadiazol-2-yl]-6-methoxy-phenoxy}-acetamide

HRID 152844Notes

Reaction equation

HRID 152844 reaction equation
[Br:66][CH2:67][C:68](=[O:69])[NH2:70].[CH3:44][CH2:45][CH2:46][CH2:47][N+:48]([CH2:49][CH2:50][CH2:51][CH3:52])([CH2:53][CH2:54][CH2:55][CH3:56])[CH2:57][CH2:58][CH2:59][CH3:60].[F-:43].[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]2=[N:9][N:10]([C:32](=[O:33])[c:34]3[c:35]([F:42])[cH:36][c:37]([F:41])[cH:38][c:39]3[F:40])[CH:11]([c:13]3[c:14]([O:21][Si:22]([CH:23]([CH3:24])[CH3:25])([CH:26]([CH3:27])[CH3:28])[CH:29]([CH3:30])[CH3:31])[c:15]([O:19][CH3:20])[cH:16][cH:17][cH:18]3)[S:12]2)[cH:6][cH:7]1.[O:61]1[CH2:62][CH2:63][CH2:64][CH2:65]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]2=[N:9][N:10]([C:32](=[O:33])[c:34]3[c:35]([F:42])[cH:36][c:37]([F:41])[cH:38][c:39]3[F:40])[CH:11]([c:13]3[c:14]([O:21][CH2:67][C:68](=[O:69])[NH2:70])[c:15]([O:19][CH3:20])[cH:16][cH:17][cH:18]3)[S:12]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 696322-BromoacetamideHCID 67279689[5-(4-Fluoro-phenyl)-2-(3-methoxy-2-triisopropylsilanyloxy-phenyl)-[1,3,4]thiadiazol-3-yl]-(2,4,6-trifluoro-phenyl)-methanone

Product 1

HCID 580258272-{2-[5-(4-Fluoro-phenyl)-3-(2,4,6-trifluoro-benzoyl)-2,3-dihydro-[1,3,4]thiadiazol-2-yl]-6-methoxy-phenoxy}-acetamide

Sources & evidence

ORD record
ord-199c53d624714bfa99e4d36defc186dd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…