(2-(tert-Butyl)thiazol-4-yl)methanamine → N-((2-tert-butylthiazol-4-yl)methyl)-4-(4-chlorophenyl)-5-(cyclopropylmethoxy)picolinamide

HRID 1528456Notes

Reaction equation

HRID 1528456 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][CH:16]3[CH2:18][CH2:17]3)=[CH:12][N:11]=[C:10]([C:19]([OH:21])=O)[CH:9]=2)=[CH:4][CH:3]=1.[CH3:22][C:23]([C:26]1[S:27][CH:28]=[C:29]([CH2:31][NH2:32])[N:30]=1)([CH3:25])[CH3:24]>>[C:23]([C:26]1[S:27][CH:28]=[C:29]([CH2:31][NH:32][C:19](=[O:21])[C:10]2[CH:9]=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[C:13]([O:14][CH2:15][CH:16]3[CH2:17][CH2:18]3)=[CH:12][N:11]=2)[N:30]=1)([CH3:25])([CH3:22])[CH3:24]

Participants

3

Reactant 2

HCID 16494974(2-(tert-Butyl)thiazol-4-yl)methanamineHCID 666786854-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 56928903N-((2-tert-butylthiazol-4-yl)methyl)-4-(4-chlorophenyl)-5-(cyclopropylmethoxy)picolinamide

Procedure

The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-(cyclopropylmethyloxy)-pyridine-2-carboxylic acid (example H) and 2-(1,1-dimethylethyl)-4-thiazolemethanamine (CAN 937656-81-0) as starting materials; LC-MS (UV peak area/ESI) 100%, 456.1491 (M+H)+.

Sources & evidence

ORD record
ord-abaa417ff26841adbfa4e013040e37f1
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

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