(2-(tert-Butyl)thiazol-4-yl)methanamine → N-((2-tert-butylthiazol-4-yl)methyl)-4-(4-chlorophenyl)-5-(cyclopropylmethoxy)picolinamide

Participants

Role	Name	HCID	Charge
Reactant	(2-(tert-Butyl)thiazol-4-yl)methanamine	HCID 16494974	—
Reactant	4-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid	HCID 66678685	—
Product	N-((2-tert-butylthiazol-4-yl)methyl)-4-(4-chlorophenyl)-5-(cyclopropylmethoxy)picolinamide	HCID 56928903	—

Reaction Steps

The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-(cyclopropylmethyloxy)-pyridine-2-carboxylic acid (example H) and 2-(1,1-dimethylethyl)-4-thiazolemethanamine (CAN 937656-81-0) as starting materials; LC-MS (UV peak area/ESI) 100%, 456.1491 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09090599B2
Source dataset	uspto-grants-2015_07
ORD ID	ord-abaa417ff26841adbfa4e013040e37f1
Source note	uspto-grants-2015_07