Dimethylamine → HCID 67997831, compound

HRID 1528571Notes

Reaction equation

HRID 1528571 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:11]([OH:13])=O)[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[CH3:14][NH:15][CH3:16]>>[CH3:14][N:15]([CH3:16])[C:11]([C:8]1([C:5]2[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][N:6]=2)[CH2:10][CH2:9]1)=[O:13]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 694761531-(5-Bromopyridin-2-yl)cyclopropane-1-carboxylic acid

Product 1

HCID 67997831HCID 67997831, compound

Procedure

The title compound was prepared from 1-(5-bromo-pyridin-2-yl)-cyclopropanecarboxylic acid and dimethylamine (2 mol/L in tetrahydrofuran) following a procedure analogous to that described in Step 2 for Intermediate 5. Yield: quantitative; LC (method 1): tR=1.65 min; Mass spectrum (ESI+): m/z=269/271 (Br) [M+H]+.

Sources & evidence

ORD record
ord-96dd983e097d433eacfd7bff421ddf0e
Source dataset
uspto-grants-2015_07
Patent number
US09090605B2

Reaction notes

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