Ethylenediamine → HCID 33698057, compound

HRID 1528591Notes

Reaction equation

HRID 1528591 reaction equation
[CH2:1]([NH2:4])[CH2:2][NH2:3].[Br:5][C:6]1[CH:7]=[N:8][C:9](Cl)=[N:10][CH:11]=1.C(N(CC)CC)C>C(O)C>[Br:5][C:6]1[CH:7]=[N:8][C:9]([NH:3][CH2:2][CH2:1][NH2:4])=[N:10][CH:11]=1

Participants

5

Reactant 3

HCID 3301EthylenediamineHCID 8471TriethylamineHCID 6066655-Bromo-2-chloropyrimidine

Product 1

HCID 33698057HCID 33698057, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethane-1,2-diamine (200 mg) was added to a solution of 5-bromo-2-chloro-pyrimidine (500 mg) and triethylamine (1 mL) in ethanol (10 mL) at 0° C. The reaction mixture was stirred under nitrogen at room temperature overnight. The formed mixture was concentrated to give crude N1-(5-bromopyrimidin-2-yl)ethane-1,2-diamine. Yield: 687 mg (100% of theory).

Workup

  1. concentrationThe formed mixture was concentrated

Sources & evidence

ORD record
ord-9c8e2e06ca7f48c5ade0131f34d90cb8
Source dataset
uspto-grants-2015_07
Patent number
US09090605B2

Reaction notes

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