Methyl iodide → HCID 66578085, compound

HRID 1528816Notes

Reaction equation

HRID 1528816 reaction equation
[CH3:1][C:2]1[C:6]([CH2:7][CH2:8][C:9](=[O:17])[NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:5]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([C:30]4([C:33]([OH:35])=[O:34])[CH2:32][CH2:31]4)=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)[O:4][N:3]=1.I[CH3:37]>C1COCC1>[CH3:1][C:2]1[C:6]([CH2:7][CH2:8][C:9](=[O:17])[N:10]([CH3:37])[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[C:5]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:25]=[CH:26][C:27]([C:30]4([C:33]([OH:35])=[O:34])[CH2:32][CH2:31]4)=[CH:28][CH:29]=3)=[CH:20][CH:19]=2)[O:4][N:3]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 66578006HCID 66578006, compound

Product 1

HCID 66578085HCID 66578085, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared according to the procedure described in Example 34, Step 4, using THF as the solvent and the following starting materials: 1-{4′-[3-methyl-4-(2-phenylcarbamoyl-ethyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid and iodomethane.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-4d24f640e4ab44d2882937e92b53fbf4
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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