Triphenylphosphine → HCID 86673638, compound

HRID 1528848Notes

Reaction equation

HRID 1528848 reaction equation
[Br:1][CH2:2][C:3]1[C:4]([CH3:15])=[N:5][O:6][C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][CH:9]=1.[C:16]1([P:22]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C1(C)C=CC=CC=1>[Br-:1].[Br:14][C:11]1[CH:12]=[CH:13][C:8]([C:7]2[O:6][N:5]=[C:4]([CH3:15])[C:3]=2[CH2:2][P+:22]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 665772234-Bromomethyl-5-(4-bromo-phenyl)-3-methyl-isoxazole

Product 1

HCID 86673638HCID 86673638, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
75 °C

Procedure

4-Bromomethyl-5-(4-bromo-phenyl)-3-methyl-isoxazole (0.8066 g, 2.44 mmol) and triphenylphosphine (0.7026 g, 2.68 mmol) were combined in toluene (8 mL) and heated to 75° C. for 75 minutes. Analytical LCMS indicated complete conversion so the reaction was cooled, filtered (rinsing with toluene) and concentrated to afford the title compound, which was used in the next step without further purification.

Workup

  1. temperaturewas cooled
  2. filtrationfiltered
  3. wash(rinsing with toluene)
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-597f9dd0fddc44a9972d949ceb722de4
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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