Cyclopentyl Isocyanate → HCID 66578103, compound

HRID 1528903Notes

Reaction equation

HRID 1528903 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH2:14][OH:15])=[CH:4][CH:3]=1.[CH:16]1([N:21]=[C:22]=[O:23])[CH2:20][CH2:19][CH2:18][CH2:17]1>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH2:14][O:15][C:22](=[O:23])[NH:21][CH:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 643500Cyclopentyl IsocyanateHCID 58218538[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol

Product 1

HCID 66578103HCID 66578103, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
120 °C

Procedure

[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol (0.120 g, 0.45 mmol) was mixed with cyclopentyl isocyanate (0.075 g, 0.68 mmol) in toluene and the reaction was heated to 120° C. overnight. After cooling, the crude material was submitted directly to silica gel purification to afford the title compound.

Workup

  1. temperatureAfter cooling
  2. customthe crude material was submitted directly to silica gel purification

Sources & evidence

ORD record
ord-ce8410e55957447d9ab320e16f885dd7
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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