4-[3-(Trifluoromethyl)phenyl]butan-2-one → (4'-{3-Methyl-4-[1-methyl-3-(3-trifluoromethyl-phenyl)-propylamino]-isoxazol-5-yl}-biphenyl-4-yl)-acetic acid ethyl ester

HRID 1528938Notes

Reaction equation

HRID 1528938 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[O:22][N:21]=[C:20]([CH3:23])[C:19]=3[NH2:24])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1)[CH3:2].[F:26][C:27]([F:40])([F:39])[C:28]1[CH:29]=[C:30]([CH2:34][CH2:35][C:36](=O)[CH3:37])[CH:31]=[CH:32][CH:33]=1>>[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[O:22][N:21]=[C:20]([CH3:23])[C:19]=3[NH:24][CH:36]([CH3:37])[CH2:35][CH2:34][C:30]3[CH:31]=[CH:32][CH:33]=[C:28]([C:27]([F:26])([F:39])[F:40])[CH:29]=3)=[CH:14][CH:13]=2)=[CH:10][CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 133390594-[3-(Trifluoromethyl)phenyl]butan-2-oneHCID 66577589Ethyl 2-(4'-(4-amino-3-methylisoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acetate

Product 1

HCID 66582074(4'-{3-Methyl-4-[1-methyl-3-(3-trifluoromethyl-phenyl)-propylamino]-isoxazol-5-yl}-biphenyl-4-yl)-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 24, Step 1, using [4′-(4-amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]acetic acid ethyl ester and 4-(3-trifluoromethyl-phenyl)-butan-2-one.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a97ca043094f43d4b35c1791ce3a62c9
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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