4-(3-Chlorophenyl)butan-2-one → (4'-{4-[3-(3-Chloro-phenyl)-1-methyl-propylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-acetic acid ethyl ester

HRID 1528939Notes

Reaction equation

HRID 1528939 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[O:22][N:21]=[C:20]([CH3:23])[C:19]=3[NH2:24])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1)[CH3:2].[Cl:26][C:27]1[CH:28]=[C:29]([CH2:33][CH2:34][C:35](=O)[CH3:36])[CH:30]=[CH:31][CH:32]=1>>[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[O:22][N:21]=[C:20]([CH3:23])[C:19]=3[NH:24][CH:35]([CH3:36])[CH2:34][CH2:33][C:29]3[CH:30]=[CH:31][CH:32]=[C:27]([Cl:26])[CH:28]=3)=[CH:14][CH:13]=2)=[CH:10][CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 2604324-(3-Chlorophenyl)butan-2-oneHCID 66577589Ethyl 2-(4'-(4-amino-3-methylisoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acetate

Product 1

HCID 66578083(4'-{4-[3-(3-Chloro-phenyl)-1-methyl-propylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 24, Step 1, using [4′-(4-amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-acetic acid ethyl ester and 4-(3-chloro-phenyl)-butan-2-one.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-616e4cd07b3e4a8389831e3b0aa86ede
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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