Ethyl 2-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)acetate → {4'-[4-(4-Hydroxy-1-methyl-butylamino)-3-methyl-isoxazol-5-yl]-biphenyl-2-yl}-acetic acid ethyl ester

HRID 1529008Notes

Reaction equation

HRID 1529008 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[NH:14][CH:15]([CH3:20])[CH2:16][CH2:17][CH2:18][OH:19])=[CH:4][CH:3]=1.[CH2:21]([O:23][C:24](=[O:41])[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1B1OC(C)(C)C(C)(C)O1)[CH3:22]>>[CH2:21]([O:23][C:24](=[O:41])[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[NH:14][CH:15]([CH3:20])[CH2:16][CH2:17][CH2:18][OH:19])=[CH:4][CH:3]=1)[CH3:22]

Participants

3

Reactant 2

HCID 58539376Ethyl 2-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)acetateHCID 665782724-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-ylamino]-pentan-1-ol

Product 1

HCID 66582070{4'-[4-(4-Hydroxy-1-methyl-butylamino)-3-methyl-isoxazol-5-yl]-biphenyl-2-yl}-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 7, using 4-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-ylamino]-pentan-1-ol and [2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-67bb6f5616dd48c08b2fcf48b4aeec74
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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