反应详情

10.000 g (38.021 mmol) of 5-fluoro-3-iodo-1H-pyrazolo[3,4-b]pyridine and 13.627 g (41.823 mmol) of cesium carbonate were initially charged in 270 ml of DMF, and 8.785 g (41.823 mmol) of (iodomethyl)cyclopentane were added. The reaction mixture was stirred at RT overnight, diluted with water and extracted with ethyl acetate. The organic phase was dried over sodium sulfate and concentrated on a rotary evaporator. This gave 6.370 g of the target compound (purity 83%, 49% of theory), which was reacted further as a crude product.

1. extractionextracted with ethyl acetate
2. dry with materialThe organic phase was dried over sodium sulfate
3. concentrationconcentrated on a rotary evaporator
4. customThis gave 6.370 g of the target compound (purity 83%, 49% of theory), which was reacted further as a crude product