Potassium Carbonate → 5-ethynyl-N-methylpyridin-2-amine

HRID 1529203ノート

反応式

HRID 1529203 の反応式
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]#[C:10][Si](C)(C)C)=[CH:5][N:4]=1.C([O-])([O-])=O.[K+].[K+]>CO>[C:9]([C:6]1[CH:7]=[CH:8][C:3]([NH:2][CH3:1])=[N:4][CH:5]=1)#[CH:10]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 66705950Methyl-(5-trimethylsilanylethynyl-pyridin-2-yl)-amine

生成物 1

HCID 226631285-ethynyl-N-methylpyridin-2-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The title compound is synthesized according to general procedure GP3 starting from 1.5 g (7.3 mmol) methyl-(5-trimethylsilanylethynyl-pyridin-2-yl)-amine (A6) and 507 mg (3.7 mmol) K2CO3 in 10 mL MeOH. Yield: 698 mg (56%) after chromatography on silica gel.

出典と根拠

ORDレコード
ord-bc6b3ed0855547b995134c3c3f7a7666
出典データセット
uspto-grants-2015_07
特許番号
US09090564B2

反応ノート

読み込み中…