Sodium Hydroxide → HCID 58235202, compound

HRID 1529212Notes

Reaction equation

HRID 1529212 reaction equation
C[O:2][C:3](=[O:27])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH3:16])[C:11]=2[C:17]#[C:18][C:19]2[CH:20]=[N:21][C:22]([NH2:25])=[CH:23][CH:24]=2)=[CH:6][C:5]=1[F:26].[OH-].[Na+]>C1COCC1>[NH2:25][C:22]1[N:21]=[CH:20][C:19]([C:18]#[C:17][C:11]2[C:12]([CH3:16])=[N:13][CH:14]=[CH:15][C:10]=2[C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:27])=[O:2])=[C:5]([F:26])[CH:6]=2)=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58235301HCID 58235301, compound

Product 1

HCID 58235202HCID 58235202, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound is synthesized according to general procedure GP4 starting from 300 mg (0.83 mmol) 4-[3-(6-amino-pyridin-3-ylethynyl)-2-methyl-pyridin-4-yl]-2-fluoro-benzoic acid methyl ester using 0.83 mL (0.83 mmoL) 1 N NaOH in 5 mL THF. The precipitate is collected by filtration and washed with THF. Yield: 280 mg (97%).

Workup

  1. filtrationThe precipitate is collected by filtration
  2. washwashed with THF

Sources & evidence

ORD record
ord-a80aff0253cb4ed2a5ed64d20e403d3a
Source dataset
uspto-grants-2015_07
Patent number
US09090564B2

Reaction notes

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