tert-butyl (3R)-3-aminopiperidine-1-carboxylate → (R)-tert-butyl 3-((4-chloro-6-methoxypyrimidin-2-yl)amino)piperidine-1-carboxylate

HRID 1529422Notes

Reaction equation

HRID 1529422 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([N:10]2[CH2:15][CH2:14][CH:13](NC(=O)OC(C)(C)C)[CH2:12]C2)[N:3]=1.ClC1N=C(Cl)C=C(OC)N=1.N[C@@H]1CCC[N:37]([C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[CH2:36]1>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([NH:10][C@@H:15]2[CH2:14][CH2:13][CH2:12][N:37]([C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[CH2:36]2)[N:3]=1

Participants

4

Reactant 3

HCID 1501974tert-butyl (3R)-3-aminopiperidine-1-carboxylateHCID 38245092,4-Dichloro-6-methoxypyrimidineHCID 86709788Tert-butyl (1-(4-chloro-6-methoxypyrimidin-2-yl)piperidin-4-yl)carbamate

Product 1

HCID 86709791(R)-tert-butyl 3-((4-chloro-6-methoxypyrimidin-2-yl)amino)piperidine-1-carboxylate

Procedure

The title compound was prepared according to the procedure for compound 276a, using 2,4-dichloro-6-methoxypyrimidine and (R)-tert-butyl 3-aminopiperidine-1-carboxylate.

Sources & evidence

ORD record
ord-661bdd27d707437e9d2689cda51a7ef9
Source dataset
uspto-grants-2015_07
Patent number
US09090593B2

Reaction notes

Loading…