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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1529422Generated: November 2, 2026

tert-butyl (3R)-3-aminopiperidine-1-carboxylate → (R)-tert-butyl 3-((4-chloro-6-methoxypyrimidin-2-yl)amino)piperidine-1-carboxylate

https://huagongshe.com/reaction/1529422

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-butyl (3R)-3-aminopiperidine-1-carboxylateHCID 1501974—
Reactant2,4-Dichloro-6-methoxypyrimidineHCID 3824509—
ReactantTert-butyl (1-(4-chloro-6-methoxypyrimidin-2-yl)piperidin-4-yl)carbamateHCID 86709788—
Product(R)-tert-butyl 3-((4-chloro-6-methoxypyrimidin-2-yl)amino)piperidine-1-carboxylateHCID 86709791—

Reaction Steps

The title compound was prepared according to the procedure for compound 276a, using 2,4-dichloro-6-methoxypyrimidine and (R)-tert-butyl 3-aminopiperidine-1-carboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09090593B2
Source datasetuspto-grants-2015_07
ORD IDord-661bdd27d707437e9d2689cda51a7ef9
Source noteuspto-grants-2015_07