Potassium Carbonate → HCID 67013968, compound

Participants

Reaction Steps

Commercially available dichloropyrimidines were reacted with a 4-aminopiperidine in tetrahydrofuran in the presence of potassium carbonate at room temperature. After 16 hours, the reaction mixture was diluted with dichloromethane and the potassium carbonate was filtered off. The solvent was removed and the crude reaction mixture was purified by column chromatography on silicagel to give a pyrimidine-piperidine intermediate. Further the intermediate was reacted with the desired diamine compound in refluxing butanol. The compound of Formula I was isolated after column chromatography on silicagel.

Provenance & Evidence