Potassium Carbonate → HCID 67013968, compound

HRID 1529465Notes

Reaction equation

HRID 1529465 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+]>O1CCCC1.ClCCl>[N:1]1[CH:2]=[CH:7][CH:6]=[N:5][CH:4]=1.[NH:5]1[CH2:6][CH2:7][CH2:2][CH2:3][CH2:4]1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 4243614-Piperidinamine

Product 1

HCID 67013968HCID 67013968, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolvent

Procedure

Commercially available dichloropyrimidines were reacted with a 4-aminopiperidine in tetrahydrofuran in the presence of potassium carbonate at room temperature. After 16 hours, the reaction mixture was diluted with dichloromethane and the potassium carbonate was filtered off. The solvent was removed and the crude reaction mixture was purified by column chromatography on silicagel to give a pyrimidine-piperidine intermediate. Further the intermediate was reacted with the desired diamine compound in refluxing butanol. The compound of Formula I was isolated after column chromatography on silicagel.

Workup

  1. filtrationthe potassium carbonate was filtered off
  2. customThe solvent was removed
  3. customthe crude reaction mixture
  4. customwas purified by column chromatography on silicagel

Sources & evidence

ORD record
ord-28bde53ef01e4e698010edf98329a88f
Source dataset
uspto-grants-2015_07
Patent number
US09090624B2

Reaction notes

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