huagongshe.com
HRID1529506

反应详情

EQUATION

反应方程式

HRID 1529506 的结构方程式

REACTANTS

反应物

3
结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CN1C[C@@H](N)CCC1=O
HCID28064098

未命名化合物

结构：Clc1nc(Cl)c2c(n1)CCS2
HCID45789967

2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

C6H4Cl2N2S

PRODUCTS

生成物

1
结构：CN1C[C@@H](Nc2nc(Cl)nc3c2SCC3)CCC1=O
HCID59708467

(5S)-5-[(2-Chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)amino]-1-methyl-2-piperidinone

C12H15ClN4OS

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

CONDITIONS

反应条件

温度
130 °C

PROCEDURE

实验过程

0.27 g (II) are placed in 3 ml dioxane, then 0.45 ml diisopropylethylamine are added followed by 0.25 g (S)-5-amino-1-methylpiperidin-2-one. The reaction mixture is heated to 130° C. until there is no further reaction, and after cooling evaporated down. The product is extracted with dichloromethane and purified by chromatography (preparative HPLC, method A). 0.26 g (III-2) are obtained as a solid. Analytical

WORKUP

后处理

  1. customno further reaction
  2. temperatureafter cooling
  3. customevaporated down
  4. extractionThe product is extracted with dichloromethane
  5. custompurified by chromatography (preparative HPLC, method A)
  6. custom0.26 g (III-2) are obtained as a solid