反应详情

温度

75 °C

To a stirred solution of [(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]-3-nitrobenzoate (0.640 g, 1.30 mmol) in anhydrous tetrahydrofuran (30.0 mL) was added tin chloride dihydrate (1.18 g, 5.2 mmol). After heating at 75° C. for 16 hours, the reaction was allowed to cool to room temperature. The reaction was partitioned between ethyl acetate and sodium bicarbonate and extracted with ethyl acetate (×2). The combined organic extracts were dried on magnesium sulphate, filtered and the solvent was removed in vacuo to afford the title compound as a brown solid (0.520 g, 87% yield).

1. temperatureto cool to room temperature
2. customThe reaction was partitioned between ethyl acetate and sodium bicarbonate
3. extractionextracted with ethyl acetate (×2)
4. customThe combined organic extracts were dried on magnesium sulphate
5. filtrationfiltered
6. customthe solvent was removed in vacuo