反应详情

To a solution of 4-chloro-5,6,7,8-tetrahydrobenzo[1,2-b]pyrimidino[5,4-d]selenophene (600 mg, 2.20 mmol, from step b of example 1) in DMF (10 mL) was added sequentially 4-aminopyrazine (310 mg, 3.30 mmol) and powdered NaOH (260 mg, 6.60 mmol) at rt. Work-up as described in example 2, gave the product as a pale yellow color solid (470 mg, 65%), mp 192-194° C. 1H NMR (400 MHz, CDCl3): δ 9.94 (1H, s), 8.56 (1H, s), 8.29 (1H, s), 8.23 (1H, s), 7.93 (1H, s, exchangeable with D2O), 3.14 (2H, s), 2.96 (2H, s), 2.01 (2H, s), 1.95 (2H, s); 13C NMR (100 MHz, CDCl3): δ 171.9, 153.4, 151.5, 149.1, 141.9, 138.8, 137.7, 126.7, 120.1, 28.2, 28.1, 22.7, 22.5; LC-MS (negative ion mode): m/z 328, 330 (M−H)−.