反应详情

A mixture of 10-chloro-5,6-dihydroimidazo[1,2-d]pyrido[4,3-f][1,4]oxazepine-2-carboxamide (1.290 g, 4.875 mmol) and 1,1-Dimethoxy-N,N-dimethylmethanamine (3.238 mL, 24.37 mmol) in 70 ml of toluene was heated under reflux for 1 hour. After cooling the product precipitated from the reaction mixture, collected, washed with ethyl ether and dried on air. Weight 0.705 g (85%). MS (ESI+): 320.1

1. temperaturewas heated
2. temperatureunder reflux for 1 hour
3. temperatureAfter cooling the product
4. customprecipitated from the reaction mixture
5. customcollected
6. washwashed with ethyl ether
7. customdried on air