反应详情

Methyl 2-iodo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-9-carboxylate (740, 2.3 mmol) and copper cyanide (537 mg, 6.9 mmol) were mixed in DMF (8 mL). The reaction was microwaved on 200 watts, 150° C. for 40 minutes. The reaction mixture was partitioned between 15% ammonia in water and EtOAc. The aqueous layer was extracted with EtOAc three times, combined organic extracts were washed with water, brine and dried over MgSO4 to produce 0.46 g (74% yield) of methyl 2-cyano-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-9-carboxylate.

1. customThe reaction was microwaved on 200 watts, 150° C. for 40 minutes
2. customThe reaction mixture was partitioned between 15% ammonia in water and EtOAc
3. extractionThe aqueous layer was extracted with EtOAc three times
4. washwere washed with water, brine
5. dry with materialdried over MgSO4