Lithium Hydroxide → HCID 67050697, compound

HRID 1530496Notes

Reaction equation

HRID 1530496 reaction equation
[CH3:1][CH:2]([N:4]1[C:8]([C:9]2[N:10]=[C:11]3[N:21]([CH:22]=2)[CH2:20][CH2:19][O:18][C:17]2[C:12]3=[CH:13][C:14]([C:23]([O:25]C)=[O:24])=[CH:15][CH:16]=2)=[N:7][CH:6]=[N:5]1)[CH3:3].[Li+].[OH-]>CO>[CH3:3][CH:2]([N:4]1[C:8]([C:9]2[N:10]=[C:11]3[N:21]([CH:22]=2)[CH2:20][CH2:19][O:18][C:17]2[C:12]3=[CH:13][C:14]([C:23]([OH:25])=[O:24])=[CH:15][CH:16]=2)=[N:7][CH:6]=[N:5]1)[CH3:1]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 68312674HCID 68312674, compound

Product 1

HCID 67050697HCID 67050697, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of methyl 4-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca1(14),2,4,10,12-pentaene-13-carboxylate (1.40 g, 3.95 mmol) in MeOH (25 ml) was added LiOH (2.0 N, 10 ml). The resulting solution was heated to reflux for overnight. The volatiles were removed in vacuo and the residue was adjusted to pH around 6-7 using 1 N HCl. The solid was collected and dried under reduce pressure to give the desired product (1.0 g, 75% yield) as a brown solid. LCMS m/z [M+H]+ 340.2.

Workup

  1. temperatureThe resulting solution was heated
  2. temperatureto reflux for overnight
  3. customThe volatiles were removed in vacuo
  4. customThe solid was collected
  5. customdried

Sources & evidence

ORD record
ord-cf561af9e19e490985040b975d175e38
Source dataset
uspto-grants-2015_07
Patent number
US09090628B2

Reaction notes

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