反应详情

To a solution of tert-butyl 3-(1-methyl-1H-pyrazol-5-yl)piperidine-1-carboxylate (680 mg, 2.50 mmol) in THF (20 mL) was added NBS (486 mg, 2.80 mmol). The reaction mixture was stirred for 2 h. After concentration, the residue was purified by silica gel chromatography eluting with a 0-50% gradient of EtOAc in petroleum ether to give tert-butyl

1. concentrationAfter concentration
2. customthe residue was purified by silica gel chromatography
3. washeluting with a 0-50% gradient of EtOAc in petroleum ether
4. customto give tert-butyl