80214-83-1 → HCID 178455840, compound

HRID 1530770Notes

Reaction equation

HRID 1530770 reaction equation
[CH3:1][CH2:2][C@H:3]1[O:25][C:23](=[O:24])[C@H:22]([CH3:26])[C@@H:21]([O:27][C@@H:28]2[O:33][C@@H:32]([CH3:34])[C@H:31]([OH:35])[C@@:30]([O:37][CH3:38])([CH3:36])[CH2:29]2)[C@H:20]([CH3:39])[C@@H:19]([O:40][C@@H:41]2[O:46][C@H:45]([CH3:47])[CH2:44][C@H:43]([N:48]([CH3:50])[CH3:49])[C@H:42]2[OH:51])[C@@:18]([OH:53])([CH3:52])[CH2:17][C@@H:16]([CH3:54])/[C:7](=[N:8]\[O:9][CH2:10][O:11][CH2:12][CH2:13][O:14][CH3:15])/[C@H:6]([CH3:55])[C@@H:5]([OH:56])[C@@:4]1([OH:58])[CH3:57]>C(Cl)Cl>[CH3:1][CH2:2][C@H:3]1[O:25][C:23](=[O:24])[C@H:22]([CH3:26])[C@@H:21]([O:27][C@@H:28]2[O:33][C@@H:32]([CH3:34])[C@H:31]([OH:35])[C@@:30]([O:37][CH3:38])([CH3:36])[CH2:29]2)[C@H:20]([CH3:39])[C@@H:19]([O:40][C@@H:41]2[O:46][C@H:45]([CH3:47])[CH2:44][C@H:43]([N:48]([CH3:49])[CH3:50])[C@H:42]2[O:51][CH2:10][O:11][CH2:12][CH2:13][O:14][CH3:15])[C@@:18]([OH:53])([CH3:52])[CH2:17][C@@H:16]([CH3:54])/[C:7](=[N:8]/[O:9][CH2:10][O:11][CH2:12][CH2:13][O:14][CH3:15])/[C@H:6]([CH3:55])[C@@H:5]([OH:56])[C@@:4]1([OH:58])[CH3:57]

Participants

3

Reactant 1

HCID 691574480214-83-1

Product 1

HCID 178455840HCID 178455840, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Roxithromycin (30 grams) was dissolved in a solution of Eudragit RS100 (70 grams) in methylene chloride (560 grams). The solution was pumped through an atomising nozzle into a spray drier with an inlet air temperature of 55° C. The powder was collected and suspended in a 0.05M glycine buffer at pH 10 containing 1% polyvinylpyrollidone. The taste due to the roxithromycin was not detectable 5 days after preparation.

Workup

  1. customThe solution was pumped through an atomising nozzle into a spray drier with an inlet
  2. customair temperature of 55° C
  3. customThe powder was collected
  4. additioncontaining 1% polyvinylpyrollidone
  5. customafter preparation

Sources & evidence

ORD record
ord-767b984824324bc7ba21e9cfd952d031
Source dataset
uspto-grants-2001_03
Patent number
US06197348B1

Reaction notes

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