4546-70-7 → Adenosine

HRID 1530777Notes

Reaction equation

[C@@H]1(N2C3N=C(N)NC(=O)C=3N=C2)O[C@H](CO)[C@@H]([OH:4])C1.[CH2:20]1[C@H:24]([N:25]2[C:29]3[N:30]=[C:31](N)[N:32]=[C:33]([NH2:34])[C:28]=3[N:27]=[CH:26]2)[O:23][C@H:22]([CH2:36][OH:37])[C@H:21]1[OH:38]>>[C@@H:24]1([N:25]2[C:29]3[N:30]=[CH:31][N:32]=[C:33]([NH2:34])[C:28]=3[N:27]=[CH:26]2)[O:23][C@H:22]([CH2:36][OH:37])[C@@H:21]([OH:38])[C@H:20]1[OH:4]

Participants

Reactant 2

HCID 971884546-70-7

HCID 135398592Deoxyguanosine

Product 1

HCID 60961Adenosine

Procedure

It is possible to prepare 2′-deoxyguanosine by putting 2,6-diaminopurine-2′-deoxyriboside obtained above under the action of an adenosine deaminase or a material containing said enzyme in an aqueous medium. The action of the adenosine deaminase may either be effected on 2,6-diaminopurine-2′-deoxyriboside in the reaction solution described above without separation or on a product separated from the mixture after reaction. The method for collection or separation includes a method using a synthetic adsorption resin and other routine collecting or separating methods.

Sources & evidence

ORD record: ord-61779fc2196e4e679ca37c7a1ba89885
Source dataset: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06197552B1

Reaction notes

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