Water → HCID 21252696, compound

HRID 1530794Notes

Reaction equation

HRID 1530794 reaction equation
[F:1][CH:2]([CH:6]1[CH2:15][CH2:14][C:9]2(OCC[O:10]2)[CH2:8][CH2:7]1)[CH:3]([F:5])[F:4].O.C(=O)([O-])[O-].[K+].[K+]>C(O)=O>[F:1][CH:2]([CH:6]1[CH2:15][CH2:14][C:9](=[O:10])[CH2:8][CH2:7]1)[CH:3]([F:4])[F:5]

Participants

5

Reactant 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 21252704HCID 21252704, compound

Product 1

HCID 21252696HCID 21252696, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

At 20 to 25° C., 6.2 g of 8-(1,2,2-trifluoroethyl)-1,4-dioxaspiro[4.5]decane were stirred in 40 ml of formic acid for 16 h. The reaction solution was subsequently poured into water, adjusted to pH 8 using potassium carbonate, extracted with methylene chloride and the organic phase was dried and concentrated to give the title product as a colourless oil which was reacted further without any purification.

Workup

  1. extractionextracted with methylene chloride
  2. customthe organic phase was dried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-5fc35b5555b042feb3491f458107b3c6
Source dataset
uspto-grants-2001_03
Patent number
US06197729B1

Reaction notes

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