Ammonia → HCID 21252685, compound

HRID 1530795Notes

Reaction equation

HRID 1530795 reaction equation
[H][H].[F:3][CH:4]([CH:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)[CH:5]([F:7])[F:6].[NH3:15]>[Rh]>[F:3][CH:4]([CH:8]1[CH2:13][CH2:12][CH:11]([NH2:15])[CH2:10][CH2:9]1)[CH:5]([F:7])[F:6]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 21252696HCID 21252696, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21252685HCID 21252685, compound

Reagents, catalysts & solvents 1

HCID 23948RhodiumCatalyst

Procedure

At 50° C. and 20 bar hydrogen pressure, 4.7 g of 4-(1,2,2-trifluoroethyl)cyclohexanone were reductively aminated in 100 ml of ammonia-saturated methanol in an autoclave using rhodium on carbon as catalyst. The catalyst was filtered off and the reaction solution was concentrated, giving the title product as a brown oil which was reacted further without any purification.

Workup

  1. customAt 50° C.
  2. filtrationThe catalyst was filtered off
  3. concentrationthe reaction solution was concentrated

Sources & evidence

ORD record
ord-e0a61c6e504641d795e19a88901bd6e9
Source dataset
uspto-grants-2001_03
Patent number
US06197729B1

Reaction notes

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