Water → HCID 67367802, compound

HRID 1530798Notes

Reaction equation

HRID 1530798 reaction equation
[F:1][C:2]([F:6])([F:5])[CH:3]=[CH2:4].[CH2:7]([O:14][C:15]1[CH:20]=[CH:19][C:18](I)=[CH:17][CH:16]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C([O-])(=O)C.[K+].O>CO.Cl[Pd]Cl>[CH2:7]([O:14][C:15]1[CH:20]=[CH:19][C:18]([CH:4]=[CH:3][C:2]([F:6])([F:5])[F:1])=[CH:17][CH:16]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

7

Reactant 4

HCID 962WaterHCID 126723,3,3-TrifluoropropeneHCID 517044Potassium AcetateHCID 5196711-(Benzyloxy)-4-iodobenzene

Product 1

HCID 67367802HCID 67367802, compound

Reagents, catalysts & solvents 2

HCID 24290Palladium ChlorideCatalystHCID 887MethanolSolvent

Procedure

At 130° C., 96 g of 3,3,3-trifluoropropene, 155 g of 1-benzyloxy-4-iodobenzene, 68.5 g of potassium acetate and 0.85 g of PdCl2 in 750 ml of methanol were reacted in an autoclave for 20 hours. After cooling to room temperature, the reaction mixture was mixed with water and extracted with ether. The combined organic phases were washed with water, dried and concentrated to give the title product as a colourless crystalline powder, which was reacted further without any purification.

Workup

  1. extractionextracted with ether
  2. washThe combined organic phases were washed with water
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-b0fced934cb24e449233abfe1830817f
Source dataset
uspto-grants-2001_03
Patent number
US06197729B1

Reaction notes

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