Water → HCID 21252715, compound

HRID 1530807Notes

Reaction equation

HRID 1530807 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1)(O)[CH3:4].O.C1(C)C=CC(S(O)(=O)=O)=CC=1.O>C(O)(=O)C>[F:1][C:2]([F:14])([F:15])[C:3]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1)=[CH2:4]

Participants

5

Reactant 3

HCID 962WaterHCID 521998p-Toluenesulfonic acid monohydrateHCID 108677871,1,1-Trifluoro-2-(4-methoxyphenyl)propan-2-ol

Product 1

HCID 21252715HCID 21252715, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

9.0 g of 1,1,1-trifluoro-2-(4-methoxyphenyl)-2-propanol were heated with 0.4 g of p-toluenesulfonic acid hydrate in 30 ml of glacial acetic acid until the elimination of water had ended. The reaction solution was concentrated, the residue was taken up in water, neutralised with aqueous sodium hydrogen carbonate and extracted with ethyl acetate. The extract was washed with water, dried and concentrated. Distillation of the residue under reduced pressure (5.1×10−1 torr) gave the title product as a colourless oil.

Workup

  1. concentrationThe reaction solution was concentrated
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with water
  4. customdried
  5. concentrationconcentrated
  6. distillationDistillation of the residue under reduced pressure (5.1×10−1 torr)

Sources & evidence

ORD record
ord-79ba604dcc6042cf9953967e866af418
Source dataset
uspto-grants-2001_03
Patent number
US06197729B1

Reaction notes

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