反应详情

9.0 g of 1,1,1-trifluoro-2-(4-methoxyphenyl)-2-propanol were heated with 0.4 g of p-toluenesulfonic acid hydrate in 30 ml of glacial acetic acid until the elimination of water had ended. The reaction solution was concentrated, the residue was taken up in water, neutralised with aqueous sodium hydrogen carbonate and extracted with ethyl acetate. The extract was washed with water, dried and concentrated. Distillation of the residue under reduced pressure (5.1×10−1 torr) gave the title product as a colourless oil.

1. concentrationThe reaction solution was concentrated
2. extractionextracted with ethyl acetate
3. washThe extract was washed with water
4. customdried
5. concentrationconcentrated
6. distillationDistillation of the residue under reduced pressure (5.1×10−1 torr)