HCID 178500968, compound → HCID 178500967, compound

HRID 1530813Notes

Reaction equation

HRID 1530813 reaction equation
C([NH:8][C@@H:9]1[CH2:14][CH2:13][C@H:12]([CH:15]([C:20]([O:22][CH3:23])=[O:21])[C:16]([O:18][CH3:19])=[O:17])[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[NH2:8][C@@H:9]1[CH2:10][CH2:11][C@H:12]([CH:15]([C:16]([O:18][CH3:19])=[O:17])[C:20]([O:22][CH3:23])=[O:21])[CH2:13][CH2:14]1

Participants

4

Reactant 1

HCID 178500968HCID 178500968, compound

Product 1

HCID 178500967HCID 178500967, compoundYield 96.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

23.0 g of dimethyl (cis-4-benzylaminocyclohexyl)malonate were dissolved in 200 ml of methanol and hydrogenated at 30 bar and 50° C. in the presence of 2 g of palladium catalyst (5% on carbon). Removal of the catalyst by filtration and subsequent concentration gave 16.0 g of the title product as a colourless oil.

Workup

  1. customRemoval of the catalyst
  2. filtrationby filtration and subsequent concentration

Sources & evidence

ORD record
ord-50f383b40c404ce0b4640dcce518c620
Source dataset
uspto-grants-2001_03
Patent number
US06197729B1

Reaction notes

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