Sodium borohydride → 4-(Benzyloxy)-alpha-(trifluoromethyl)benzyl Alcohol

HRID 1530815노트

반응식

HRID 1530815 반응식
[BH4-].[Na+].[CH2:3]([O:10][C:11]1[CH:16]=[CH:15][C:14]([C:17](=[O:22])[C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>O.C(O)C>[CH2:3]([O:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]([OH:22])[C:18]([F:19])([F:20])[F:21])=[CH:13][CH:12]=1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 212526911-(4-(Benzyloxy)phenyl)-2,2,2-trifluoroethanone

생성물 1

HCID 212526644-(Benzyloxy)-alpha-(trifluoromethyl)benzyl Alcohol

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

At 20° C., a solution of 15.7 g of sodium borohydride in 100 ml of water was added dropwise with cooling to a solution of 72.5 g of 4′-benzyloxy-2,2,2-trifluoroacetophenone in 900 ml of ethanol. The mixture was stirred under reflux for 3 hours and then concentrated, the residue was taken up in diethyl ether and water and made slightly acidic using dilute hydrochloric acid, and the organic phase was dried and concentrated to give the title product as a colourless oil.

후처리

  1. temperatureunder reflux for 3 hours
  2. concentrationconcentrated
  3. customthe organic phase was dried
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4a92d3c83db041b38275b9daed4ffa74
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06197729B1

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