4-(Benzyloxy)-alpha-(trifluoromethyl)benzyl Alcohol → 4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol

Participants

Reaction Steps

At 50° C. and a hydrogen pressure of 5 bar, 65.7 g (233 mmol) of 1-benzyloxy-4-(1-hydroxy-2,2,2-trifluoroethyl)benzene were hydrogenated in the presence of 5.2 g of palladium (10% on carbon) in 500 ml of glacial acetic acid. The catalyst was filtered off and the mixture was concentrated. This gave 44.1 g (99% of theory) of the product as a colourless oil.

Provenance & Evidence