4-(Benzyloxy)-alpha-(trifluoromethyl)benzyl Alcohol → 4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol

HRID 1530816Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1530816
[H][H].C([O:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]([OH:22])[C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=1)C1C=CC=CC=1>C(O)(=O)C.[Pd]>[OH:22][CH:17]([C:14]1[CH:15]=[CH:16][C:11]([OH:10])=[CH:12][CH:13]=1)[C:18]([F:20])([F:21])[F:19]

Komponenten

5

Edukt 2

HCID 212526644-(Benzyloxy)-alpha-(trifluoromethyl)benzyl AlcoholHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 112869774-(2,2,2-Trifluoro-1-hydroxyethyl)phenol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

At 50° C. and a hydrogen pressure of 5 bar, 65.7 g (233 mmol) of 1-benzyloxy-4-(1-hydroxy-2,2,2-trifluoroethyl)benzene were hydrogenated in the presence of 5.2 g of palladium (10% on carbon) in 500 ml of glacial acetic acid. The catalyst was filtered off and the mixture was concentrated. This gave 44.1 g (99% of theory) of the product as a colourless oil.

Aufarbeitung

  1. customAt 50° C.
  2. filtrationThe catalyst was filtered off
  3. concentrationthe mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-166f643d580845d6bac7ff1b171f6f5c
Quelldatensatz
uspto-grants-2001_03
Patentnummer
US06197729B1

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