反应详情

At 50° C. and a hydrogen pressure of 5 bar, 43.0 g of 4-(1-hydroxy-2,2,2-trifluoroethyl)cyclohexanone and 24.0 g of benzylamine in 400 ml of methanol were hydrogenated in the presence of 1.5 g of platinum (5% on carbon). The catalyst was filtered off and the mixture was concentrated. The cis/trans isomers were separated by silica gel chromatography (ethyl acetate/ethanol 9:1). The cis isomer eluted first of the two isomers, to give the title product as a colourless oil.

1. customAt 50° C.
2. filtrationThe catalyst was filtered off
3. concentrationthe mixture was concentrated
4. customThe cis/trans isomers were separated by silica gel chromatography (ethyl acetate/ethanol 9:1)
5. washThe cis isomer eluted first of the two isomers