Trifluoroacetic acid → 3-Methyl-3(2,4,6-trimethoxyphenylmethylthio)butyric acid

HRID 1530827Notes

Reaction equation

HRID 1530827 reaction equation
[SH:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4]([OH:6])=[O:5].FC(F)(F)C(O)=O.[CH3:16][O:17][C:18]1[CH:25]=[C:24]([O:26][CH3:27])[CH:23]=[C:22]([O:28][CH3:29])[C:19]=1[CH2:20]O>C(Cl)Cl>[CH3:7][C:2]([S:1][CH2:20][C:19]1[C:22]([O:28][CH3:29])=[CH:23][C:24]([O:26][CH3:27])=[CH:25][C:18]=1[O:17][CH3:16])([CH3:8])[CH2:3][C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 6025152,4,6-Trimethoxybenzyl alcoholHCID 98127863-Methyl-3-sulfanylbutanoic acid

Product 1

HCID 154581393-Methyl-3(2,4,6-trimethoxyphenylmethylthio)butyric acidYield 70%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of 3-mercapto-3-methylbutyric acid (B. J. Sweetman et al. J. Med. Chem., 14, 868 (1971)) (4.6 g. 34 mmol) in methylene chloride (250 mL) under nitrogen and cooled over ice/salt to 5 {dot over (u)}C (internal temperature) was added trifluoroacetic acid (82 g, 0.72 mol). No significant temperature rise was noted during the addition. To this was then added dropwise a solution of 2,4,6-trimethoxybenzyl alcohol (M. C. Munson et al., J. Org. Chem., 57, 3013 (1992)) (6.45 g, 32 mmol) in methylene chloride (150 mL) such that the reaction temperature does not rise above 5 {dot over (u)}C. After the addition was complete, the mixture was stirred for an additional 5 min at 5 {dot over (u)}C and the volatiles were removed in vacuo (toluene or ethyl acetate can be used to assist in the removal of volatile material). The residue was partitioned between diethyl ether and water and the organic phase dried over anhydrous sodium sulfate, filtered and the volatile material removed in vacuo. The residue was treated with activated charcoal and recrystallized from diethyl ether/hexane. The product was isolated as an white solid in 70% yield (7 g) mp 103-105° C. 1H NMR (CDCl3) δ6.12 (s, 2H), 3.80-3.85 (m, 11H), 2.74 (s, 2H), 1.47 (s, 6H). 13C NMR (CDCl3) δ173.9, 160.6, 158.6, 105.6, 90.5, 55.7, 55.3, 45.9, 43.6, 28.4, 21.0.

Workup

  1. additionNo significant temperature rise was noted during the addition
  2. additionAfter the addition
  3. customthe volatiles were removed in vacuo (toluene or ethyl acetate
  4. customto assist in the removal of volatile material)
  5. customThe residue was partitioned between diethyl ether and water
  6. dry with materialthe organic phase dried over anhydrous sodium sulfate
  7. filtrationfiltered
  8. customthe volatile material removed in vacuo
  9. additionThe residue was treated with activated charcoal
  10. customrecrystallized from diethyl ether/hexane
  11. customThe product was isolated as an white solid in 70% yield (7 g) mp 103-105° C

Sources & evidence

ORD record
ord-595ca533e06346aead25fb51a8c8f2e4
Source dataset
uspto-grants-2001_03
Patent number
US06197762B1

Reaction notes

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