Trifluoroacetic acid → HCID 69745714, compound

HRID 1530860Notes

Reaction equation

HRID 1530860 reaction equation
FC(F)(F)C(O)=O.[Si:8]([O:25][CH:26]([CH2:48][O:49]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:27][O:28][C:29](=[O:47])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]/[CH:37]=[CH:38]\[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46])([C:21]([CH3:24])([CH3:23])[CH3:22])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>ClCCl>[Si:8]([O:25][CH:26]([CH2:48][OH:49])[CH2:27][O:28][C:29](=[O:47])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]/[CH:37]=[CH:38]\[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46])([C:21]([CH3:22])([CH3:24])[CH3:23])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69746545HCID 69746545, compound

Product 1

HCID 69745714HCID 69745714, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4 ml of trifluoroacetic acid is slowly dropped into a solution of 4 (4.65 mmol) in 50 ml of dichloromethane at room temperature. After 3 hours, this is washed with water and saturated sodium hydrogen carbonate solution. The combined organic phases are dried over MgSO4, filtrated and concentrated. The residue is purified on silica gel by flash chromatography using isohexane/ethyl acetate (7:1). Yield: 54% of a colorless oil.

Workup

  1. washthis is washed with water and saturated sodium hydrogen carbonate solution
  2. dry with materialThe combined organic phases are dried over MgSO4
  3. filtrationfiltrated
  4. concentrationconcentrated
  5. customThe residue is purified on silica gel by flash chromatography

Sources & evidence

ORD record
ord-8f280ca814d04ff38eb9c2d1e14bb474
Source dataset
uspto-grants-2001_03
Patent number
US06197759B1

Reaction notes

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