Water → HCID 19364922, compound

HRID 1530994Notes

Reaction equation

HRID 1530994 reaction equation
[Br:1][C:2]1[CH:14]=[CH:13][C:12]2[C:11]3[C:6]4=[C:7]([C:24](=[O:27])[CH:25]=[CH:26][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([O:15][CH2:16][C:17]([O:19]C(C)(C)C)=[O:18])[CH:10]=3.O>C(O)(=O)C.Br>[Br:1][C:2]1[CH:14]=[CH:13][C:12]2[C:11]3[C:6]4=[C:7]([C:24](=[O:27])[CH:25]=[CH:26][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([O:15][CH2:16][C:17]([OH:19])=[O:18])[CH:10]=3

Participants

5

Reactant 2

HCID 962WaterHCID 21252854HCID 21252854, compound

Product 1

HCID 19364922HCID 19364922, compoundYield 92.1%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolvent

Procedure

9-bromo-2-t-butoxycarbonylmethyloxy-4H-pyrido[3,2,1-jk]carbazole-4-one (120 mg) produced in Example 118 was dissolved in acetic acid (5 ml) and 48% HBr (5 ml), and the solution was stirred at room temperature for 12 hours. The reaction mixture was poured into water and the crystals precipitated were recovered by filtration, and washed with water, ethanol and ether in succession to obtain the title compound (96 mg, 92%).

Workup

  1. customthe crystals precipitated
  2. filtrationwere recovered by filtration
  3. washwashed with water, ethanol and ether in succession

Sources & evidence

ORD record
ord-7951876555dc440ab1f07ada605266c5
Source dataset
uspto-grants-2001_03
Patent number
US06197768B1

Reaction notes

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