Methanol → HCID 18416700, compound

HRID 1531142Notes

Reaction equation

HRID 1531142 reaction equation
C([O:3][C:4]([C:6]1([S:19]([C:22]2[CH:27]=[CH:26][C:25]([O:28][CH2:29][CH2:30][CH2:31][CH3:32])=[CH:24][CH:23]=2)(=[O:21])=[O:20])[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[CH2:8][CH2:7]1)=[O:5])C.CO.[OH-].[Na+]>C1COCC1>[CH2:29]([O:28][C:25]1[CH:26]=[CH:27][C:22]([S:19]([C:6]2([C:4]([OH:5])=[O:3])[CH2:7][CH2:8][N:9]([CH2:12][C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[CH2:10][CH2:11]2)(=[O:20])=[O:21])=[CH:23][CH:24]=1)[CH2:30][CH2:31][CH3:32]

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 57186700HCID 57186700, compound

Product 1

HCID 18416700HCID 18416700, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4-(4-Butoxy-benzenesulfonyl)-1-pyridin-4-ylmethyl-piperidine-4-carboxylic acid was prepared starting from 4-(4-Butoxy-benzenesulfonyl)-1-pyridin-4-ylmethyl-piperidine-4-carboxylic acid ethyl ester (3.0 g, 6.5 mmol) dissolved in THF:Methanol (75: 50 ml) and 10 N NaOH (20 ml). The resulting reaction mixture was worked up as outlined in example 83. Yield 1.2 g (42%); off white solid; MS: 433.0 (M+H)+

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-37f8672e343e483c94d840af18210b00
Source dataset
uspto-grants-2001_03
Patent number
US06197791B1

Reaction notes

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