反应详情

A mixture of sodium 4-(2-cyclopentylethoxy)-benzenesulfonate (2.5 grams, 8.6 mmole), thionyl chloride (15 mL), and a few drops of N,N-dimethylformamide was heated at reflux for 5 hours. After cooling, the excess thionyl chloride was evaporated and the residue was taken up in ethyl acetate. The solution was cooled in an ice bath and water was added. The organic phase was separated and washed with water and brine. After drying over sodium sulfate, the solvent was evaporated to afford the title compound as an oil, 2.24 grams (90%).

1. temperaturewas heated
2. temperatureat reflux for 5 hours
3. temperatureAfter cooling
4. customthe excess thionyl chloride was evaporated
5. temperatureThe solution was cooled in an ice bath
6. additionwater was added
7. customThe organic phase was separated
8. washwashed with water and brine
9. dry with materialAfter drying over sodium sulfate
10. customthe solvent was evaporated