反应详情

5% Palladium-carbon (catalytic amount) was added into the solution of (1S,5R,6R,7R)-6-{(E)-4,4-difluoro-5-oxo-2-octenyl}-7-tetrahydropyranyloxy-2-oxabicyclo-[3.3.0]octan-3-one (4) (5.57 g) in ethyl acetate, and mixed at a room temperature for 7 hours under hydrogen gas atmosphere. The reaction solution was filtered, and the filtrate was concentrated under a reduced pressure to give the titled compound (5) as a crude product. Yield: 5.48 g (97.8%)

1. additionmixed at a room temperature for 7 hours under hydrogen gas atmosphere
2. filtrationThe reaction solution was filtered
3. concentrationthe filtrate was concentrated under a reduced pressure