Sodium borohydride → HCID 22842860, compound

Participants

Reaction Steps

Sodium borohydride (0.800 g) was added to the solution of (1S,5R,6R,7R)-6-(4,4-difluoro-5-oxo-octenyl)-7-tetrahydropyranyloxy-2-oxabicyclo[3.3.0]-octan-3-one (5) (5.48 g) in methanol at 0° C., and stirred for 10 minutes. The reaction product was treated with a usual manner, and the obtained crude product was subjected to column chromatography to give a titled compound (6). Yield: 5.46 g (99.5%)

Provenance & Evidence