HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromobenzoyl chloride → N-(2-acetylamino-indan-5-yl)-2-bromo-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromobenzoyl chloride | HCID 23542 | — |
| Reactant | 4''-Trifluoromethyl-biphenyl-2-carboxylic acid (2-benzenesulfonylamino-indan-5-yl)-amide | HCID 9893362 | — |
| Reactant | N-(5-amino-2,3-dihydro-1H-inden-2-yl)acetamide | HCID 14820513 | — |
| Reactant | {5-[(4'-Trifluoromethylbiphenyl-2-carbonyl)-amino]indan-2-yl}-carbamic acid tert-butyl ester | HCID 70184229 | — |
| Product | N-(2-acetylamino-indan-5-yl)-2-bromo-benzamide | HCID 21253364 | — |
Reaction Steps
The title compound is prepared as described for {5-[(4′-trifluoromethylbiphenyl-2-carbonyl)-amino]-indan-2-yl}-carbamic acid tert-butyl ester (the title E compound of Example 1) using N-(5-amino-indan-2-yl)-acetamide (the title A compound; 1.05 g, 5.50 mmol) and 2-bromo-benzoyl chloride (the title B compound; 1.21 g, 5.50 mmol) to give the product, mp 216-217° C. MS (ES+), m/z 373 (M+H), 375 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06197798B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-14678bccf9ae4227a86ac8b601d05706 |
| Source note | uspto-grants-2001_03 |