反应详情

A solution of the compound of Example 5, N-(indan-5-yl)-5-nitro-2-thiophen-2-yl-benzamide (0.083 g, 0.228 mmol) in ethyl acetate (10 mL) is degassed and 10% palladium on carbon added. The reaction mixture is evacuated and placed under 1 atm H2(g) for 16 h. Filtration of the reaction mixture through Celite is followed by concentration of the filtrate under reduced pressure to give 5-amino-N-(indan-5-yl)-2-(thiophen-2-yl)-benzamide as an oil which foams to a solid on treatment with diethyl ether. mp 62-67° C. MS (ES+), m/z 335 (M+1).

1. customThe reaction mixture is evacuated
2. filtrationFiltration of the reaction mixture through Celite