Sodium Carbonate → HCID 22498801, compound

HRID 1531309Notes

Reaction equation

HRID 1531309 reaction equation
[CH:1]1[C:6]2[CH2:7][CH2:8][C:9](=O)[CH2:10][CH2:11][C:5]=2[CH:4]=[CH:3][CH:2]=1.Cl.[NH2:14][OH:15].C(=O)([O-])[O-].[Na+].[Na+]>O>[OH:15][NH:14][CH:9]1[CH2:8][CH2:7][C:6]2[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=2[CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 122344855,6,8,9-Tetrahydro-7H-benzo[7]annulen-7-one

Product 1

HCID 22498801HCID 22498801, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To 6,7,8,9-tetrahydro-5H-benzocyclohepten-7-one (2.56 g, 16 mmol) and hydroxylamine hydrochloride (2.2 g, 32 mmol) in 27 mL of water is slowly added a solution of sodium carbonate (1.69 g, 16 mmol) in 14 mL of water. The mixture is stirred overnight. The solid is then filtered off, washed with water, and dried at 50° C. under reduced pressure to give 6,7,8,9-tetrahydro-N-hydroxy-5H-benzocyclohepten-7-amine as a white solid.

Workup

  1. filtrationThe solid is then filtered off
  2. washwashed with water
  3. customdried at 50° C. under reduced pressure

Sources & evidence

ORD record
ord-8683af5e9cad45c592b1df88033e7b31
Source dataset
uspto-grants-2001_03
Patent number
US06197798B1

Reaction notes

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