(4-Methoxyphenyl)boronic acid → HCID 70114191, compound

HRID 1531323Notes

Reaction equation

HRID 1531323 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([S:15]([C:18]([NH2:33])([CH2:23][C:24]#[C:25][CH2:26][N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)[C:19]([O:21]C)=[O:20])(=[O:17])=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.COC1C=CC(B(O)O)=CC=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12]([S:15]([C:18]([NH2:33])([CH2:23][C:24]#[C:25][CH2:26][N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)[C:19]([OH:21])=[O:20])(=[O:17])=[O:16])=[CH:13][CH:14]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 201262(4-Methoxyphenyl)boronic acidHCID 70115533HCID 70115533, compound

Product 1

HCID 70114191HCID 70114191, compound

Procedure

Methyl 2-{[4′-methoxy-(1,1′-biphenyl)-4-yl]-sulfonyl}-amino-6-morpholinohex-4-ynoate: The starting sulfonamide 34a (500 mg, 1.02 mmol) is coupled to 4-methoxyphenyl-boronic acid (233 mg, 1.53 mmol) as described for compound 32a to give the title compound as a light brown solid.

Sources & evidence

ORD record
ord-a7280a31163a4390b7306b0e6c308098
Source dataset
uspto-grants-2001_03
Patent number
US06197770B1

Reaction notes

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