HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Pyridin-4-YL-butyric acid hydrochloride → 4-Piperidine butyric acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Pyridin-4-YL-butyric acid hydrochloride | HCID 46735945 | — |
| Catalyst | Rhodium | HCID 23948 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Piperidine butyric acid hydrochloride | HCID 16217040 | 98% |
Reaction Steps
The procedure of Example 1 was repeated except the following. The same reactor as used in Example 1 was charged with 25.0 g (0.124 mole) of a γ-(4-pyridyl)butyric acid hydrochloride with a purity of at least 99%, 25.0 g of water and 1.25 g of 5% Rh/C [0.25% by weight in terms of Rh based on the γ-(4-pyridyl)butyric acid hydrochloride]. The reaction was conducted for 3 hours. A γ-(4-piperidyl)butyric acid hydrochloride was produced in a yield of 98%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06197961B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-fe0d91d6e7b74fdb9f26651f20dbb22b |
| Source note | uspto-grants-2001_03 |