4-Pyridin-4-YL-butyric acid hydrochloride → 4-Piperidine butyric acid hydrochloride

HRID 1531358Notes

Reaction equation

HRID 1531358 reaction equation
[ClH:1].[N:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:4][CH:3]=1>[Rh].O>[ClH:1].[NH:2]1[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH2:4][CH2:3]1

Participants

4

Reactant 1

HCID 467359454-Pyridin-4-YL-butyric acid hydrochloride2×

Product 1

HCID 162170404-Piperidine butyric acid hydrochlorideYield 97%

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 962WaterSolvent

Procedure

The same procedure as in Example 1 was repeated except the following. The same reactor as used in Example 1 was charged with 13.5 g (0.067 mole) of a γ-(4-pyridyl)butyric acid hydrochloride with a purity of at least 99%, 27.0 g of water and 0.67 g of 5% Rh/C [0.25% by weight in terms of Rh based on the γ-(4-pyridyl)butyric acid hydrochloride]. The reaction was conducted at 60° C. for 8 hours. A γ-(4-piperidyl)butyric acid hydrochloride was produced in a yield of 97%.

Sources & evidence

ORD record
ord-503f4de51c064f3a8aa592e2797ee214
Source dataset
uspto-grants-2001_03
Patent number
US06197961B1

Reaction notes

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