Trifluoroacetic acid → HCID 57191721, compound

HRID 1531438Notes

Reaction equation

HRID 1531438 reaction equation
[Cl:1][C:2](=[CH:10][C:11]1[CH:16]=[C:15]([C:17]2[C:21]([Cl:22])=[C:20]([O:23][CH:24]([F:26])[F:25])[N:19]([CH3:27])[N:18]=2)[C:14]([F:28])=[CH:13][C:12]=1[Cl:29])[C:3]([O:5]C(C)(C)C)=[O:4].FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2](=[CH:10][C:11]1[CH:16]=[C:15]([C:17]2[C:21]([Cl:22])=[C:20]([O:23][CH:24]([F:25])[F:26])[N:19]([CH3:27])[N:18]=2)[C:14]([F:28])=[CH:13][C:12]=1[Cl:29])[C:3]([OH:5])=[O:4]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57033571HCID 57033571, compound

Product 1

HCID 57191721HCID 57191721, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 44 g of tert-butyl 2-chloro-3-(2-chloro-5-(4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazol-3-yl)-4-fluorophenyl)acrylate (93 mmol) in 200 ml of dichloromethane was treated with 200 ml of trifluoroacetic acid. After the mixture had been stirred for 16 hours, it was concentrated. The residue was recrystallized from hexane/ethyl acetate (2:1). Yield: 23 g; a further 4 g by concentrating the mother liquor.

Workup

  1. concentrationit was concentrated
  2. customThe residue was recrystallized from hexane/ethyl acetate (2:1)
  3. concentrationa further 4 g by concentrating the mother liquor

Sources & evidence

ORD record
ord-f25d3bc8780f428c9c08ad26a6b61277
Source dataset
uspto-grants-2001_03
Patent number
US06197973B1

Reaction notes

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